{"id":499,"date":"2025-08-15T06:55:15","date_gmt":"2025-08-15T06:55:15","guid":{"rendered":"https:\/\/lwfzyzmd.com\/product\/%e8%8e%ab%e6%b4%9b%e6%9b%bf%e5%b0%bc-%e9%80%82%e7%94%a8%e4%ba%8e%e6%b2%bb%e7%96%97%e4%b8%ad%e5%ba%a6%e6%88%96%e9%ab%98%e9%a3%8e%e9%99%a9%e9%aa%a8%e9%ab%93%e7%ba%a4%e7%bb%b4%e5%8c%96-mf-%e5%8c%85\/"},"modified":"2026-09-23T00:37:58","modified_gmt":"2026-09-22T17:37:58","slug":"%e8%8e%ab%e6%b4%9b%e6%9b%bf%e5%b0%bc-%e9%80%82%e7%94%a8%e4%ba%8e%e6%b2%bb%e7%96%97%e4%b8%ad%e5%ba%a6%e6%88%96%e9%ab%98%e9%a3%8e%e9%99%a9%e9%aa%a8%e9%ab%93%e7%ba%a4%e7%bb%b4%e5%8c%96-mf-%e5%8c%85","status":"publish","type":"product","link":"https:\/\/lwfzyzmd.com\/th\/product\/%e8%8e%ab%e6%b4%9b%e6%9b%bf%e5%b0%bc-%e9%80%82%e7%94%a8%e4%ba%8e%e6%b2%bb%e7%96%97%e4%b8%ad%e5%ba%a6%e6%88%96%e9%ab%98%e9%a3%8e%e9%99%a9%e9%aa%a8%e9%ab%93%e7%ba%a4%e7%bb%b4%e5%8c%96-mf-%e5%8c%85\/","title":{"rendered":"Lucius LuciMomel Momelotinib 100mg"},"content":{"rendered":"<p><strong>\u83ab\u6d1b\u66ff\u5c3c\u8bf4\u660e\u4e66<\/strong><\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p>\u5546\u54c1\u540d\u79f0\uff1aLuciMomel<\/p>\n<p>\u751f\u4ea7\u5546\uff1a\u5362\u4fee\u65af\u5236\u836f Lucius<\/p>\n<p>\u4e2d\u6587\u540d\u79f0\uff1a\u83ab\u6d1b\u66ff\u5c3c<\/p>\n<p>\u82f1\u6587\u540d\u79f0\uff1aMomelotinib<\/p>\n<p>\u836f\u54c1\u6279\u51c6\u6587\u53f7\uff1a06 L 1113\/24<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u3010\u6982\u62ec\u3011<\/strong><\/p>\n<p>momelotinib\u662f\u91ce\u751f\u578bJanus\u6fc0\u91761\u548c2(JAK1\/JAK2)\u548c\u7a81\u53d8\u4f53JAK2V617F\u7684\u6291\u5236\u5242\uff0c\u5176\u6709\u52a9\u4e8e\u5bf9\u9020\u8840\u548c\u514d\u75ab\u529f\u80fd\u91cd\u8981\u7684\u8bb8\u591a\u7ec6\u80de\u56e0\u5b50\u548c\u751f\u957f\u56e0\u5b50\u7684\u4fe1\u53f7\u4f20\u5bfc\u3002\u4e0eJAK3\u548c\u916a\u6c28\u9178\u6fc0\u91762 (TYK2)\u76f8\u6bd4\uff0cmomelotinib\u53ca\u5176\u4e3b\u8981\u4eba\u7c7b\u5faa\u73af\u4ee3\u8c22\u7269M21\u5bf9JAK2\u5177\u6709\u66f4\u9ad8\u7684\u6291\u5236\u6d3b\u6027\u3002momelotinib\u548cM21\u8fd8\u6291\u5236\u6fc0\u6d3b\u7d20A\u53d7\u4f531\u578b(ACVR1)\uff0c\u4e5f\u79f0\u4e3a\u6fc0\u6d3b\u7d20\u53d7\u4f53\u6837\u6fc0\u91762 (ALK2)\uff0c\u5176\u968f\u540e\u6291\u5236\u809d\u810fhepcidin\u8868\u8fbe\u5e76\u589e\u52a0\u94c1\u53ef\u7528\u6027\uff0c\u5bfc\u81f4\u7ea2\u7ec6\u80de\u751f\u6210\u589e\u52a0\u3002MF\u662f\u4e00\u79cd\u4e0e\u7ec4\u6210\u578b\u6fc0\u6d3b\u548cJAK\u4fe1\u53f7\u5931\u8c03\u76f8\u5173\u7684\u9aa8\u9ad3\u589e\u751f\u6027\u80bf\u7624\uff0c\u53ef\u5bfc\u81f4\u708e\u75c7\u548cACVR1\u7684\u8fc7\u5ea6\u6fc0\u6d3b\u3002JAK\u4fe1\u53f7\u62db\u52df\u5e76\u6fc0\u6d3bSTAT(\u4fe1\u53f7\u8f6c\u5bfc\u548c\u8f6c\u5f55\u6fc0\u6d3b)\u86cb\u767d\uff0c\u5bfc\u81f4\u6838\u5b9a\u4f4d\u548c\u968f\u540e\u7684\u57fa\u56e0\u8f6c\u5f55\u8c03\u8282\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u3010\u9002\u5e94\u75c7\u3011<\/strong><\/p>\n<p>\u9002\u7528\u4e8e\u6cbb\u7597\u4e2d\u5ea6\u6216\u9ad8\u98ce\u9669\u9aa8\u9ad3\u7ea4\u7ef4\u5316\uff08MF\uff09\uff0c\u5305\u62ec\u539f\u53d1\u6027\u9aa8\u9ad3\u7ea4\u7ef4\u5316\u6216\u7ee7\u53d1\u6027\u9aa8\u9ad3\u7ea4\u7ef4\u5316[\u771f\u6027\u7ea2\u7ec6\u80de\u589e\u591a\u75c7\uff08PV\uff09\u548c\u539f\u53d1\u6027\u8840\u5c0f\u677f\u589e\u591a\u75c7\uff08ET\uff09]\u7684\u6210\u4eba\u8d2b\u8840\u60a3\u8005\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u3010\u89c4\u683c\u3011\u00a0<\/strong><\/p>\n<p>100mg\/\u7c92\uff0c30\u7c92\/\u74f6<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u3010\u8d2e\u5b58\u3011<\/strong><\/p>\n<p>\u8d2e\u5b58\u4e8e20\u00b0C \uff5e25\u00b0C (68\u00b0C \uff5e77\u00b0F)\uff1b\u5141\u8bb8\u8303\u56f4\u4e3a15\uff5e30\u00b0C (59\u201386\u00b0F)\u6e29\u5ea6\u6761\u4ef6\u4e0b\u77ed\u9014\u8fd0\u8f93\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u3010\u7528\u6cd5\u7528\u91cf\u3011<\/strong><\/p>\n<p>1\u3001\u6bcf\u65e5\u53e3\u670d\u4e00\u6b21\uff0c\u6bcf\u6b21200mg\uff0c\u968f\u9910\u6216\u7a7a\u8179\u5747\u53ef\u3002<\/p>\n<p>2\u3001\u4e25\u91cd\u809d\u635f\u4f24\uff08Child-Pugh C\u7ea7\uff09\uff1a\u5c06\u8d77\u59cb\u5242\u91cf\u964d\u81f3150 mg\uff0c \u6bcf\u65e5\u53e3\u670d\u4e00\u6b21\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u3010\u4e0d\u826f\u53cd\u5e94\u3011<\/strong><\/p>\n<p>1. 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\u611f\u67d3\u7684\u98ce\u9669<\/p>\n<p>\u63a5\u53d7LuciMomel\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u670913%\u51fa\u73b0\u4e25\u91cd(\u5305\u62ec\u81f4\u547d)\u611f\u67d3(\u5982\u7ec6\u83cc\u548c\u75c5\u6bd2\uff0c\u5305\u62ec\u65b0\u51a0\u80ba\u708e)\u3002\u63a5\u53d7LuciMomel\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u670938%\u51fa\u73b0\u611f\u67d3\u3002\u5ef6\u8fdf\u5f00\u59cbLuciMomel\u6cbb\u7597\uff0c\u76f4\u5230\u6d3b\u52a8\u6027\u611f\u67d3\u6d88\u5931\u3002\u76d1\u6d4b\u63a5\u53d7LuciMomel\u6cbb\u7597\u7684\u60a3\u8005\u7684\u611f\u67d3\u8ff9\u8c61\u548c\u75c7\u72b6\uff0c\u5e76\u7acb\u5373\u5f00\u59cb\u9002\u5f53\u7684\u6cbb\u7597\u3002<\/p>\n<p>\u4e59\u578b\u809d\u708e\u518d\u6fc0\u6d3b\uff1a\u4e59\u578b\u809d\u708e\u75c5\u6bd2\u8f7d\u91cf(HBV-DNA\u6ef4\u5ea6)\u589e\u52a0\uff0c\u4f34\u6709\u6216\u4e0d\u4f34\u6709\u4e19\u6c28\u9178\u8f6c\u6c28\u9176(ALT)\u6216\u5929\u51ac\u6c28\u9178\u8f6c\u6c28\u9176(AST)\u5347\u9ad8\uff0c\u5df2\u6709\u6162\u6027\u4e59\u578b\u809d\u708e\u75c5\u6bd2(HBV)\u611f\u67d3\u60a3\u8005\u670d\u7528JAK\u6291\u5236\u5242(\u5305\u62ecLuciMomel)\u7684\u62a5\u544a\u3002LuciMomel\u5bf9\u6162\u6027HBV\u611f\u67d3\u60a3\u8005\u75c5\u6bd2\u590d\u5236\u7684\u5f71\u54cd\u5c1a\u4e0d\u6e05\u695a\u3002\u5bf9\u4e8eHBV\u611f\u67d3\u60a3\u8005\uff0c\u5728\u5f00\u59cbLuciMomel\u524d\u68c0\u67e5\u4e59\u809d\u8840\u6e05\u5b66\u3002\u5982\u679cHBsAg\u548c\/\u6216\u6297-HBc\u6297\u4f53\u5448\u9633\u6027\uff0c\u8003\u8651\u54a8\u8be2\u809d\u75c5\u5b66\u5bb6\uff0c\u4ee5\u76d1\u6d4b\u518d\u6d3b\u5316\u4e0e\u9884\u9632\u6027\u4e59\u809d\u6cbb\u7597\u3002\u63a5\u53d7LuciMomel\u6cbb\u7597\u7684\u6162\u6027HBV\u611f\u67d3\u60a3\u8005\u5e94\u6839\u636eHBV\u4e34\u5e8a\u6307\u5357\u5bf9\u5176\u6162\u6027HBV\u611f\u67d3\u8fdb\u884c\u6cbb\u7597\u548c\u76d1\u6d4b\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u4e8c\u3001 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)\uff0c\u5305\u62ec\u8840\u5c0f\u677f\u548c\u4e2d\u6027\u7c92\u7ec6\u80de\u8ba1\u6570\u3002\u5bf9\u4e8e\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u6216\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\uff0c\u4e2d\u65ad\u7ed9\u836f\u6216\u51cf\u5c11\u5242\u91cf\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u4e09\u3001 \u809d\u4e2d\u6bd2<\/p>\n<p>\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u63a5\u53d7\u81f3\u5c11\u4e00\u5242LuciMomel\u7684993\u4f8bMF\u60a3\u8005\u4e2d\uff0c\u67092\u4f8b\u51fa\u73b0\u53ef\u9006\u6027\u836f\u7269\u6027\u809d\u635f\u4f24\u3002\u603b\u7684\u6765\u8bf4\uff0c\u5728\u63a5\u53d7LuciMomel\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0cALT\u548cAST(\u6240\u6709\u7ea7\u522b)\u5206\u522b\u670923%\u548c24%\u51fa\u73b0\u65b0\u7684\u6216\u6076\u5316\u7684\u5347\u9ad8\uff1b3\u7ea7\u548c4\u7ea7\u8f6c\u6c28\u9176\u5347\u9ad8\u5206\u522b\u53d1\u751f\u57281%\u548c0.5%\u7684\u60a3\u8005\u300216%\u63a5\u53d7LuciMomel\u6cbb\u7597\u7684\u60a3\u8005\u51fa\u73b0\u65b0\u7684\u6216\u6076\u5316\u7684\u603b\u80c6\u7ea2\u7d20\u5347\u9ad8\u3002\u6240\u6709\u603b\u80c6\u7ea2\u7d20\u5347\u9ad8\u5747\u4e3a1-2\u7ea7\u3002\u4efb\u4f55\u7ea7\u522b\u8f6c\u6c28\u9176\u5347\u9ad8\u7684\u4e2d\u4f4d\u53d1\u75c5\u65f6\u95f4\u4e3a2\u4e2a\u6708\uff0c75%\u7684\u75c5\u4f8b\u53d1\u751f\u57284\u4e2a\u6708\u5185\u3002\u5bf9\u4e8e\u51fa\u73b0\u672a\u63a7\u5236\u7684\u6025\u6027\u548c\u6162\u6027\u809d\u75c5\u7684\u60a3\u8005\uff0c\u5ef6\u8fdf\u5f00\u59cb\u6cbb\u7597\uff0c\u76f4\u5230\u5df2\u7ecf\u8c03\u67e5\u4e86\u660e\u663e\u7684\u539f\u56e0\u5e76\u6839\u636e\u4e34\u5e8a\u6307\u5f81\u8fdb\u884c\u6cbb\u7597\u3002\u5728\u57fa\u7ebf\u65f6\u76d1\u6d4b\u809d\u810f\u68c0\u67e5\uff0c\u5728\u6cbb\u7597\u671f\u95f4\u6bcf\u6708\u76d1\u6d4b\u4e00\u6b21\uff0c\u6301\u7eed6\u4e2a\u6708\uff0c\u7136\u540e\u6839\u636e\u4e34\u5e8a\u6307\u5f81\u5b9a\u671f\u76d1\u6d4b\u3002\u5982\u679c\u6000\u7591\u4e0e\u6cbb\u7597\u76f8\u5173\u7684ALT\u3001AST\u6216\u80c6\u7ea2\u7d20\u5347\u9ad8\uff0c\u6839\u636e\u88681\u4fee\u6539LuciMomel\u5242\u91cf\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u56db\u3001 \u4e3b\u8981\u5fc3\u8840\u7ba1\u4e0d\u826f\u4e8b\u4ef6(MACE)<\/p>\n<p>\u53e6\u4e00\u79cdJAK\u6291\u5236\u5242\u589e\u52a0\u4e86\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u60a3\u8005\u53d1\u751fMACE\u7684\u98ce\u9669\uff0c\u5305\u62ec\u5fc3\u8840\u7ba1\u6b7b\u4ea1\u3001\u5fc3\u808c\u6897\u6b7b\u548c\u4e2d\u98ce[\u4e0e\u4f7f\u7528\u80bf\u7624\u574f\u6b7b\u56e0\u5b50(TNF)\u963b\u65ad\u5242\u6cbb\u7597\u7684\u60a3\u8005\u76f8\u6bd4]\u3002\u5728\u5f00\u59cb\u6216\u7ee7\u7eed\u4f7f\u7528LuciMomel\u6cbb\u7597\u524d\uff0c\u8003\u8651\u60a3\u8005\u4e2a\u4f53\u7684\u76ca\u5904\u548c\u98ce\u9669\uff0c\u5c24\u5176\u662f\u76ee\u524d\u6216\u8fc7\u53bb\u5438\u70df\u7684\u60a3\u8005\u4ee5\u53ca\u5177\u6709\u5176\u4ed6\u5fc3\u8840\u7ba1\u98ce\u9669\u56e0\u7d20\u7684\u60a3\u8005\u3002\u544a\u77e5\u63a5\u53d7LuciMomel\u6cbb\u7597\u7684\u60a3\u8005\u4e25\u91cd\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u7684\u75c7\u72b6\u4ee5\u53ca\u53d1\u751f\u8fd9\u4e9b\u75c7\u72b6\u65f6\u5e94\u91c7\u53d6\u7684\u63aa\u65bd\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u4e94\u3001 \u8840\u6813\u75c7<\/p>\n<p>\u53e6\u4e00\u79cdJAK\u6291\u5236\u5242\u589e\u52a0\u4e86\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u60a3\u8005\u8840\u6813\u5f62\u6210\u7684\u98ce\u9669\uff0c\u5305\u62ec\u6df1\u9759\u8109\u8840\u6813\u5f62\u6210\u3001\u80ba\u6813\u585e\u548c\u52a8\u8109\u8840\u6813\u5f62\u6210(\u4e0e\u7528TNF\u963b\u6ede\u5242\u6cbb\u7597\u7684\u60a3\u8005\u76f8\u6bd4)\uff0c\u8fd9\u662f\u4e00\u79cdLuciMomel\u6ca1\u6709\u9002\u5e94\u75c7\u7684\u75be\u75c5\uff0c\u8bc4\u4f30\u6709\u8840\u6813\u5f62\u6210\u75c7\u72b6\u7684\u60a3\u8005\u5e76\u8fdb\u884c\u9002\u5f53\u6cbb\u7597\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u516d\u3001 \u6076\u6027\u80bf\u7624<\/p>\n<p>\u53e6\u4e00\u79cdJAK\u6291\u5236\u5242\u589e\u52a0\u4e86\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u60a3\u8005\u4e2d\u9664\u975e\u9ed1\u8272\u7d20\u7624\u76ae\u80a4\u764c(NMSC)\u4ee5\u5916\u7684\u6dcb\u5df4\u7624\u548c\u5176\u4ed6\u6076\u6027\u80bf\u7624\u7684\u98ce\u9669(\u4e0e\u4f7f\u7528TNF\u963b\u6ede\u5242\u6cbb\u7597\u7684\u60a3\u8005\u76f8\u6bd4)\u3002\u73b0\u5728\u6216\u8fc7\u53bb\u5438\u70df\u7684\u4eba\u98ce\u9669\u66f4\u9ad8\u3002\u5728\u5f00\u59cb\u6216\u7ee7\u7eed\u4f7f\u7528LuciMomel\u6cbb\u7597\u524d\uff0c\u8003\u8651\u60a3\u8005\u4e2a\u4f53\u7684\u76ca\u5904\u548c\u98ce\u9669\uff0c\u7279\u522b\u662f\u60a3\u6709\u5df2\u77e5\u6076\u6027\u80bf\u7624\u7684\u60a3\u8005(\u9664\u4e86\u6210\u529f\u6cbb\u7597\u7684NMSC)\u3001\u53d1\u5c55\u4e3a\u6076\u6027\u80bf\u7624\u7684\u60a3\u8005\u4ee5\u53ca\u76ee\u524d\u6216\u8fc7\u53bb\u5438\u70df\u7684\u60a3\u8005\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u3010\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u3011<\/strong><\/p>\n<p>1. \u6709\u673a\u9634\u79bb\u5b50\u8f6c\u8fd0\u591a\u80bd(OATP)1B1\/B3\u6291\u5236\u5242<\/p>\n<p>&nbsp;<\/p>\n<p>LuciMomel\u662fOATP1B1\/B3\u5e95\u7269\u3002\u4e0eOATP1B1\/B3\u6291\u5236\u5242\u540c\u65f6\u4f7f\u7528\u4f1a\u589e\u52a0LuciMomel\u7684\u6700\u5927\u6d53\u5ea6(Cmax)\u548c\u6d53\u5ea6-\u65f6\u95f4\u66f2\u7ebf\u4e0b\u9762\u79ef(AUC)\uff0c\u8fd9\u53ef\u80fd\u4f1a\u589e\u52a0LuciMomel\u7684\u4e0d\u826f\u53cd\u5e94\u98ce\u9669\u3002\u76d1\u6d4b\u540c\u65f6\u63a5\u53d7OATP1B1\/B3\u6291\u5236\u5242\u6cbb\u7597\u7684\u60a3\u8005\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u5e76\u8003\u8651\u8c03\u6574LuciMomel\u5242\u91cf\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>2. \u4e73\u817a\u764c\u8010\u836f\u86cb\u767d(BCRP)\u5e95\u7269<\/p>\n<p>&nbsp;<\/p>\n<p>LuciMomel\u662f\u4e00\u79cdBCRP\u6291\u5236\u5242\u3002LuciMomel\u53ef\u80fd\u4f1a\u589e\u52a0BCRP\u5e95\u7269\u7684\u66b4\u9732\uff0c\u8fd9\u53ef\u80fd\u4f1a\u589e\u52a0BCRP\u5e95\u7269\u4e0d\u826f\u53cd\u5e94\u7684\u98ce\u9669\u3002\u5f53\u4e0eLuciMomel\u540c\u65f6\u7ed9\u836f\u65f6\uff0c\u4ee55 mg\u5f00\u59cbrosuvastatin (BCRP\u5e95\u7269),\u4e0d\u8981\u589e\u52a0\u5230\u8d85\u8fc710 mg\uff0c\u6bcf\u5929\u4e00\u6b21\u3002\u4e5f\u53ef\u80fd\u9700\u8981\u8c03\u6574\u5176\u4ed6BCRP\u5e95\u7269\u7684\u5242\u91cf\u3002\u5bf9\u4e8e\u5176\u4ed6BCRP\u5e95\u7269\uff0c\u8bf7\u9075\u5faa\u6279\u51c6\u7684\u4ea7\u54c1\u7528\u836f\u4fe1\u606f\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u3010\u7279\u6b8a\u4eba\u7fa4\u4e2d\u4f7f\u7528\u3011<\/strong><\/p>\n<p>1\u3001 \u598a\u5a20<\/p>\n<p>&nbsp;<\/p>\n<p>\u5173\u4e8e\u5b55\u5987\u4f7f\u7528LuciMomel\u7684\u73b0\u6709\u6570\u636e\u4e0d\u8db3\u4ee5\u786e\u5b9a\u662f\u5426\u5b58\u5728\u91cd\u5927\u51fa\u751f\u7f3a\u9677\u6216\u6d41\u4ea7\u7684\u836f\u7269\u76f8\u5173\u98ce\u9669\u3002\u6839\u636e\u5728\u5927\u9f20\u548c\u5154\u5b50\u4e2d\u8fdb\u884c\u7684\u52a8\u7269\u7e41\u6b96\u7814\u7a76\uff0c\u5728\u6bcf\u5929\u4e00\u6b21\u63a5\u53d7200 mg\u7684\u60a3\u8005\u4e2d\uff0cLuciMomel\u7684\u66b4\u9732\u91cf\u4f4e\u4e8e\u9884\u671f\u66b4\u9732\u91cf\u65f6\uff0c\u53ef\u80fd\u4f1a\u5bfc\u81f4\u80da\u80ce-\u80ce\u513f\u6bd2\u6027\u3002LuciMomel\u5e94\u4ec5\u5728\u5bf9\u6bcd\u4eb2\u7684\u9884\u671f\u76ca\u5904\u8d85\u8fc7\u5bf9\u80ce\u513f\u7684\u6f5c\u5728\u98ce\u9669\u7684\u60c5\u51b5\u4e0b\u5728\u6000\u5b55\u671f\u95f4\u4f7f\u7528\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>2\u3001 \u54fa\u4e73\u671f<\/p>\n<p>&nbsp;<\/p>\n<p>\u6ca1\u6709\u5173\u4e8e\u6bcd\u4e73\u4e2d\u5b58\u5728LuciMomel\u6216\u5176\u4ee3\u8c22\u7269\u3001\u5bf9\u6bcd\u4e73\u5582\u517b\u513f\u7ae5\u7684\u5f71\u54cd\u6216\u5bf9\u6ccc\u4e73\u91cf\u7684\u5f71\u54cd\u7684\u6570\u636e\u3002\u5c1a\u4e0d\u6e05\u695aLuciMomel\u662f\u5426\u901a\u8fc7\u4eba\u4e73\u6392\u6cc4\u3002\u7ecf\u6cbb\u7597\u7684\u6bcd\u9f20\u5582\u517b\u7684\u5e7c\u9f20\u4f53\u5185\u5b58\u5728LuciMomel\uff0c\u89c2\u5bdf\u5230\u5176\u540e\u4ee3\u51fa\u73b0\u4e0d\u826f\u53cd\u5e94\u3002\u5f53\u4e00\u79cd\u836f\u7269\u5b58\u5728\u4e8e\u52a8\u7269\u4e73\u6c41\u4e2d\u65f6\uff0c\u8be5\u836f\u7269\u4e5f\u53ef\u80fd\u5b58\u5728\u4e8e\u4eba\u4e73\u4e2d\u3002\u7531\u4e8e\u6bcd\u4e73\u5582\u517b\u7684\u513f\u7ae5\u53ef\u80fd\u51fa\u73b0\u4e25\u91cd\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u56e0\u6b64\u60a3\u8005\u5728\u63a5\u53d7LuciMomel\u6cbb\u7597\u671f\u95f4\u4ee5\u53ca\u6700\u540e\u4e00\u5242LuciMomel\u540e\u81f3\u5c111\u5468\u5185\u4e0d\u5e94\u8fdb\u884c\u6bcd\u4e73\u5582\u517b\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>3\u3001 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(29%)\u4e3a75\u5c81\u53ca\u4ee5\u4e0a\u3002\u5728\u5e74\u9f84\u4e3a65\u5c81\u7684\u60a3\u8005\u4e0e\u5e74\u9f84\u8f83\u5927\u548c\u8f83\u5e74\u8f7b\u7684\u6210\u5e74\u60a3\u8005\u4e4b\u95f4\uff0c\u6ca1\u6709\u89c2\u5bdf\u5230LuciMomel\u7684\u5b89\u5168\u6027\u6216\u6709\u6548\u6027\u7684\u603b\u4f53\u5dee\u5f02\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>6\u3001 \u809d\u810f\u635f\u4f24<\/p>\n<p>&nbsp;<\/p>\n<p>\u4e25\u91cd\u809d\u529f\u80fd\u635f\u5bb3(ChildPugh C)\u60a3\u8005\u53e3\u670dLuciMomel\u7684\u5efa\u8bae\u8d77\u59cb\u5242\u91cf\u4e3a150 mg\uff0c\u6bcf\u65e5\u4e00\u6b21\u3002\u5bf9\u4e8e\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u5bb3(Child-Pugh A)\u6216\u4e2d\u5ea6\u809d\u529f\u80fd\u635f\u5bb3(Child-Pugh B)\u7684\u60a3\u8005\uff0c\u4e0d\u5efa\u8bae\u8c03\u6574\u5242\u91cf\u3002LuciMomel\u88ab\u5e7f\u6cdb\u4ee3\u8c22\u3002\u968f\u7740\u4e25\u91cd\u809d\u529f\u80fd\u635f\u5bb3(Child-Pugh C )\uff0cLuciMomel\u66b4\u9732\u589e\u52a0\u3002\u5728\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u5bb3(Child-Pugh 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