{"id":537,"date":"2025-08-15T06:55:23","date_gmt":"2025-08-15T06:55:23","guid":{"rendered":"https:\/\/lwfzyzmd.com\/product\/%e5%88%a9%e7%89%b9%e6%98%94%e6%9b%bf%e5%b0%bc-%e9%80%82%e7%94%a8%e4%ba%8e12%e5%b2%81%e5%8f%8a%e4%bb%a5%e4%b8%8a%e7%9a%84%e9%9d%92%e5%b0%91%e5%b9%b4%e5%92%8c%e6%88%90%e4%ba%ba%e9%87%8d%e5%ba%a6\/"},"modified":"2026-09-23T00:36:02","modified_gmt":"2026-09-22T17:36:02","slug":"%e5%88%a9%e7%89%b9%e6%98%94%e6%9b%bf%e5%b0%bc-%e9%80%82%e7%94%a8%e4%ba%8e12%e5%b2%81%e5%8f%8a%e4%bb%a5%e4%b8%8a%e7%9a%84%e9%9d%92%e5%b0%91%e5%b9%b4%e5%92%8c%e6%88%90%e4%ba%ba%e9%87%8d%e5%ba%a6","status":"publish","type":"product","link":"https:\/\/lwfzyzmd.com\/th\/product\/%e5%88%a9%e7%89%b9%e6%98%94%e6%9b%bf%e5%b0%bc-%e9%80%82%e7%94%a8%e4%ba%8e12%e5%b2%81%e5%8f%8a%e4%bb%a5%e4%b8%8a%e7%9a%84%e9%9d%92%e5%b0%91%e5%b9%b4%e5%92%8c%e6%88%90%e4%ba%ba%e9%87%8d%e5%ba%a6\/","title":{"rendered":"Lucius LuciRit Ritlecitinib 50mg"},"content":{"rendered":"

\u5229\u7279\u6614\u66ff\u5c3c<\/strong>\u8bf4\u660e\u4e66<\/strong><\/p>\n

\u5546\u54c1\u540d\u79f0\uff1aLuciRit<\/p>\n

\u751f\u4ea7\u5546\uff1a\u5362\u4fee\u65af\u5236\u836f\u00a0Lucius<\/p>\n

\u4e2d\u6587\u540d\u79f0\uff1a\u5229\u7279\u6614\u66ff\u5c3c
\n\u82f1\u6587\u540d\u79f0\uff1aRitlecitinib<\/p>\n

\u836f\u54c1\u6279\u51c6\u6587\u53f7\uff1a10\u00a0L 1035\/23<\/p>\n

 <\/p>\n

 <\/p>\n

\u3010\u6982\u62ec\u3011<\/strong><\/p>\n

\u5229\u7279\u6614\u66ff\u5c3c(Ritlecitinib)\u662f\u4e00\u79cd\u6fc0\u9176\u6291\u5236\u5242\u00a0\uff0c\u9002\u7528\u4e8e\u6cbb\u7597\u6210\u4eba\u548c12\u5c81\u53ca\u4ee5\u4e0a\u9752\u5c11\u5e74\u7684\u91cd\u5ea6\u6591\u79c3\u3002<\/p>\n

 <\/p>\n

\u3010\u9002\u5e94\u75c7\u3011<\/strong><\/p>\n

\u9002\u7528\u4e8e\u6cbb\u7597\u6210\u4eba\u548c12\u5c81\u53ca\u4ee5\u4e0a\u9752\u5c11\u5e74\u7684\u91cd\u5ea6\u6591\u79c3\u3002<\/p>\n

\u4f7f\u7528\u9650\u5236\uff1a\u4e0d\u5efa\u8bae\u4e0e\u5176\u4ed6 JAK \u6291\u5236\u5242\u3001\u751f\u7269\u514d\u75ab\u8c03\u8282\u5242\u3001\u73af\u5b62\u83cc\u7d20\u6216\u5176\u4ed6\u5f3a\u6548\u514d\u75ab\u6291\u5236\u5242\u8054\u5408\u4f7f\u7528\u3002<\/p>\n

 <\/p>\n

\u3010\u89c4\u683c\u3011\u00a0\u00a0<\/strong><\/p>\n

50mg\/\u7c92\uff0c28\u7c92\/\u76d2\u3002<\/p>\n

 <\/p>\n

\u3010\u8d2e\u5b58\u3011<\/strong><\/p>\n

\u8d2e\u5b58\u4e8e20\u00b0C\u00a0\uff5e25\u00b0C (68\u00b0C\u00a0\uff5e77\u00b0F)\uff1b\u5141\u8bb8\u8303\u56f4\u4e3a15\uff5e30\u00b0C (59\u201386\u00b0F)\u6e29\u5ea6\u6761\u4ef6\u4e0b\u77ed\u9014\u8fd0\u8f93\u3002<\/p>\n

 <\/p>\n

\u3010\u7528\u6cd5\u7528\u91cf\u3011<\/strong><\/p>\n

\u4f7f\u7528\u5229\u7279\u6614\u66ff\u5c3c(Ritlecitinib)\u6cbb\u7597\u524d\u5e94\u6ce8\u610f\uff1a<\/p>\n

1\u3001\u7ed3\u6838\u75c5 (TB) \u611f\u67d3\uff1a\u4e0d\u5efa\u8bae\u6d3b\u52a8\u6027 TB \u60a3\u8005\u5f00\u59cb\u5229\u7279\u6614\u66ff\u5c3c(LuciRit)\u6cbb\u7597\u3002\u5bf9\u4e8e\u6f5c\u4f0f\u6027 TB \u60a3\u8005\u6216\u6f5c\u4f0f\u6027 TB \u68c0\u6d4b\u9634\u6027\u4e14 TB \u98ce\u9669\u8f83\u9ad8\u7684\u60a3\u8005\uff0c\u5728\u5f00\u59cb\u5229\u7279\u6614\u66ff\u5c3c(LuciRit)\u6cbb\u7597\u524d\u5f00\u59cb\u6f5c\u4f0f\u6027 TB \u7684\u9884\u9632\u6027\u6cbb\u7597[\u89c1\u8b66\u544a\u548c\u6ce8\u610f\u4e8b\u9879]\u3002<\/p>\n

2\u3001\u6839\u636e\u4e34\u5e8a\u6307\u5357\u8fdb\u884c\u75c5\u6bd2\u6027\u809d\u708e\u7b5b\u67e5\uff1a\u4e0d\u5efa\u8bae\u4e59\u578b\u809d\u708e\u6216\u4e19\u578b\u809d\u708e\u60a3\u8005\u5f00\u59cb\u5229\u7279\u6614\u66ff\u5c3c(LuciRit)\u6cbb\u7597[\u89c1\u8b66\u544a\u548c\u6ce8\u610f\u4e8b\u9879]\u3002<\/p>\n

3\u3001\u6dcb\u5df4\u7ec6\u80de\u7edd\u5bf9\u8ba1\u6570 (ALC) \u7684\u60a3\u8005\u4e0d\u5e94\u5f00\u59cb\u5229\u7279\u6614\u66ff\u5c3c(LuciRit)\u6cbb\u7597< 500\/mm 3\u6216\u8840\u5c0f\u677f\u8ba1\u6570 < 100,000\/mm 3[\u53c2\u89c1\u8b66\u544a\u548c\u6ce8\u610f\u4e8b\u9879]\u3002<\/p>\n

4\u3001\u6839\u636e\u73b0\u884c\u514d\u75ab\u63a5\u79cd\u6307\u5357\u66f4\u65b0\u514d\u75ab\u63a5\u79cd[\u53c2\u89c1\u8b66\u544a\u548c\u6ce8\u610f\u4e8b\u9879]\u3002<\/p>\n

\u4e00\u3001\u63a8\u8350\u5242\u91cf<\/p>\n

1\u3001\u5229\u7279\u6614\u66ff\u5c3c(Ritlecitinib)\u7684\u63a8\u8350\u5242\u91cf\u4e3a50 mg\uff0c\u53e3\u670d\uff0c\u6bcf\u65e5\u4e00\u6b21\uff0c\u53ef\u4e0e\u6216\u4e0d\u4e0e\u98df\u7269\u540c\u670d\u3002<\/p>\n

2\u3001\u6574\u7c92\u541e\u670d\u80f6\u56ca\u3002\u8bf7\u52ff\u538b\u788e\u3001\u63b0\u5f00\u6216\u5480\u56bc\u80f6\u56ca\u3002<\/p>\n

3\u3001\u5982\u679c\u6f0f\u670d\u4e00\u5242\u836f\u7269\uff0c\u5e94\u5c3d\u5feb\u8865\u670d\uff0c\u9664\u975e\u8ddd\u4e0b\u6b21\u7ed9\u836f\u65f6\u95f4\u4e0d\u8db38\u5c0f\u65f6\uff0c\u6b64\u65f6\u8df3\u8fc7\u6f0f\u670d\u7684\u5242\u91cf\u3002\u6b64\u540e\uff0c\u6309\u7167\u6b63\u5e38\u7684\u670d\u836f\u65f6\u95f4\u6062\u590d\u7ed9\u836f\u3002<\/p>\n

\u4e8c\u3001\u91cd\u5ea6\u809d\u635f\u5bb3\u60a3\u8005<\/p>\n

\u4e0d\u5efa\u8bae\u91cd\u5ea6 (Child Pugh C) \u809d\u635f\u5bb3\u60a3\u8005\u4f7f\u7528\u5229\u7279\u6614\u66ff\u5c3c(LuciRit)[\u89c1\u7279\u6b8a\u4eba\u7fa4\u7528\u836f]\u3002<\/p>\n

\u4e09\u3001\u6cbb\u7597\u4e2d\u65ad\u6216\u505c\u836f<\/p>\n

\u5982\u679c\u9700\u8981\u4e2d\u65ad\u6cbb\u7597\uff0c\u5219\u6682\u65f6\u4e2d\u65ad\u6cbb\u7597\u5c11\u4e8e6\u5468\u9884\u8ba1\u4e0d\u4f1a\u5bfc\u81f4\u91cd\u65b0\u751f\u957f\u7684\u5934\u76ae\u6bdb\u53d1\u660e\u663e\u8131\u843d\u3002<\/p>\n

\u8840\u6db2\u5b66\u5f02\u5e38<\/p>\n

\u56e0\u8840\u6db2\u5b66\u5f02\u5e38\u800c\u4e2d\u65ad\u6216\u505c\u6b62\u5229\u7279\u6614\u66ff\u5c3c(LuciRit)\u6cbb\u7597\u7684\u5efa\u8bae\u603b\u7ed3\u89c1\u4e0b\u8868\u3002<\/p>\n

\u5b9e\u9a8c\u5ba4\u76d1\u6d4b\u6307\u5357<\/p>\n\n\n\n\n\n
\u5b9e\u9a8c\u5ba4\u6307\u6807<\/strong><\/td>\n\u5efa\u8bae<\/strong><\/td>\n<\/tr>\n
\u8840\u5c0f\u677f\u8ba1\u6570<\/td>\n\u5982\u679c\u8840\u5c0f\u677f\u8ba1\u6570 < 50,000\/mm 3\uff0c\u5e94\u505c\u6b62\u6cbb\u7597<\/td>\n<\/tr>\n
\u6dcb\u5df4\u7ec6\u80de<\/td>\n\u5982\u679cALC < 500\/mm 3\uff0c\u5e94\u4e2d\u65ad\u6cbb\u7597\uff0c\u4e00\u65e6 ALC \u6062\u590d\u81f3\u8be5\u503c\u4ee5\u4e0a\uff0c\u53ef\u91cd\u65b0\u5f00\u59cb\u6cbb\u7597\u3002<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

ALC = \u6dcb\u5df4\u7ec6\u80de\u7edd\u5bf9\u8ba1\u6570\u3002<\/p>\n

\u5efa\u8bae\u5728\u6cbb\u7597\u5f00\u59cb\u524d\u548c\u6cbb\u7597\u5f00\u59cb\u540e4\u5468\u8fdb\u884c ALC \u548c\u8840\u5c0f\u677f\u8ba1\u6570\uff0c\u6b64\u540e\u6839\u636e\u5e38\u89c4\u60a3\u8005\u7ba1\u7406\u8fdb\u884c[\u89c1\u8b66\u544a\u548c\u6ce8\u610f\u4e8b\u9879]\u3002<\/p>\n

 <\/p>\n

\u3010\u4e0d\u826f\u53cd\u5e94\u3011<\/strong><\/p>\n

1\u3001\u5934\u75db\u3001\u8179\u6cfb\u3001\u75e4\u75ae\u3001\u76ae\u75b9\u3001\u53e3\u8154\u708e<\/p>\n

2\u3001\u8368\u9ebb\u75b9\u3001\u6bdb\u56ca\u708e\u3001\u53d1\u70ed\u3001\u7279\u5e94\u6027\u76ae\u708e<\/p>\n

3\u3001\u5934\u6655\u3001\u8840\u808c\u9178\u78f7\u9178\u6fc0\u9176\u5347\u9ad8\u3001\u5e26\u72b6\u75b1\u75b9\u3001\u7ea2\u7ec6\u80de\u8ba1\u6570\u964d\u4f4e<\/p>\n

 <\/p>\n

\u3010\u7981\u5fcc\u3011<\/strong><\/p>\n

\u5df2\u77e5\u5bf9\u5229\u7279\u6614\u66ff\u5c3c\u6216\u5176\u4efb\u4f55\u8f85\u6599\u8fc7\u654f\u7684\u60a3\u8005\u7981\u7528\u5229\u7279\u6614\u66ff\u5c3c(LuciRit)\u3002<\/p>\n

 <\/p>\n

\u3010\u6ce8\u610f\u4e8b\u9879\u3011<\/strong><\/p>\n

\u4e00\u3001\u4e25\u91cd\u611f\u67d3<\/p>\n

\u5728\u63a5\u53d7\u5229\u7279\u6614\u66ff\u5c3c(LuciRit)\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u62a5\u544a\u4e86\u4e25\u91cd\u611f\u67d3\u3002\u6700\u5e38\u89c1\u7684\u4e25\u91cd\u611f\u67d3\u4e3a\u9611\u5c3e\u708e\u3001COVID-19\u611f\u67d3\uff08\u5305\u62ec\u611f\u67d3\u6027\u80ba\u708e\uff09\u548c\u8113\u6bd2\u75c7 [\u53c2\u89c1\u4e0d\u826f\u53cd\u5e94]\u3002\u5728\u673a\u4f1a\u6027\u611f\u67d3\u4e2d\uff0c\u5229\u7279\u6614\u66ff\u5c3c(LuciRit)\u7ec4\u62a5\u544a\u4e86\u591a\u76ae\u533a\u5e26\u72b6\u75b1\u75b9\u3002<\/p>\n

\u6d3b\u52a8\u6027\u4e25\u91cd\u611f\u67d3\u60a3\u8005\u5e94\u907f\u514d\u4f7f\u7528\u5229\u7279\u6614\u66ff\u5c3c(LuciRit)\u3002\u5728\u4ee5\u4e0b\u60a3\u8005\u4e2d\u5f00\u59cb\u4f7f\u7528\u5229\u7279\u6614\u66ff\u5c3c(LuciRit)\u524d\uff0c\u5e94\u8003\u8651\u6cbb\u7597\u7684\u98ce\u9669\u548c\u83b7\u76ca\uff1a<\/p>\n

1)\u4f34\u6709\u6162\u6027\u6216\u590d\u53d1\u6027\u611f\u67d3<\/p>\n

2)\u66fe\u66b4\u9732\u4e8e TB<\/p>\n

3)\u6709\u4e25\u91cd\u611f\u67d3\u6216\u673a\u4f1a\u6027\u611f\u67d3\u53f2<\/p>\n

4)\u5c45\u4f4f\u5728 TB \u6d41\u884c\u533a\u6216\u771f\u83cc\u75c5\u6d41\u884c\u533a\u6216\u5728\u8be5\u533a\u65c5\u884c\u7684\u60a3\u8005<\/p>\n

5)\u60a3\u6709\u53ef\u80fd\u4f7f\u5176\u6613\u60a3\u611f\u67d3\u7684\u57fa\u7840\u75be\u75c5<\/p>\n

\u5728\u5229\u7279\u6614\u66ff\u5c3c(LuciRit)\u6cbb\u7597\u671f\u95f4\u548c\u6cbb\u7597\u540e\uff0c\u5bc6\u5207\u76d1\u6d4b\u60a3\u8005\u662f\u5426\u51fa\u73b0\u611f\u67d3\u7684\u4f53\u5f81\u548c\u75c7\u72b6\u3002\u5982\u679c\u60a3\u8005\u53d1\u751f\u4e25\u91cd\u6216\u673a\u4f1a\u6027\u611f\u67d3\uff0c\u5219\u4e2d\u65ad \u5229\u7279\u6614\u66ff\u5c3c(LuciRit)\u6cbb\u7597\u3002\u5bf9\u4e8e\u5728\u5229\u7279\u6614\u66ff\u5c3c(LuciRit)\u6cbb\u7597\u671f\u95f4\u53d1\u751f\u65b0\u611f\u67d3\u7684\u60a3\u8005\uff0c\u5e94\u53ca\u65f6\u8fdb\u884c\u514d\u75ab\u529f\u80fd\u4f4e\u4e0b\u60a3\u8005\u7684\u5168\u9762\u8bca\u65ad\u6027\u68c0\u67e5\uff0c\u5e76\u5f00\u59cb\u9002\u5f53\u7684\u6297\u83cc\u6cbb\u7597\uff0c\u540c\u65f6\u5e94\u5bf9\u60a3\u8005\u8fdb\u884c\u5bc6\u5207\u76d1\u6d4b\u3002\u4e00\u65e6\u611f\u67d3\u5f97\u5230\u63a7\u5236\uff0c\u53ef\u91cd\u65b0\u5f00\u59cb\u4f7f\u7528\u5229\u7279\u6614\u66ff\u5c3c(LuciRit)\u3002<\/p>\n

 <\/p>\n

\u80ba\u7ed3\u6838<\/p>\n

\u5f00\u59cb\u6cbb\u7597\u524d\u7b5b\u67e5\u60a3\u8005\u7684\u7ed3\u6838\u75c5 (TB)\u3002\u6d3b\u52a8\u6027 TB \u60a3\u8005\u4e0d\u5e94\u4f7f\u7528\u5229\u7279\u6614\u66ff\u5c3c(LuciRit)\u3002\u5728\u65b0\u8bca\u65ad\u4e3a\u6f5c\u4f0f\u6027 TB \u6216\u65e2\u5f80\u672a\u7ecf\u6cbb\u7597\u7684\u6f5c\u4f0f\u6027 TB \u60a3\u8005\u4e2d\uff0c\u5e94\u5728\u5f00\u59cb\u5229\u7279\u6614\u66ff\u5c3c(LuciRit)\u6cbb\u7597\u524d\u5f00\u59cb\u6297\u7ed3\u6838\u6cbb\u7597\u3002\u5728\u6f5c\u4f0f\u6027 TB \u68c0\u6d4b\u9634\u6027\u7684\u60a3\u8005\u4e2d\uff0c\u5bf9\u4e8e\u9ad8\u98ce\u9669\u60a3\u8005\uff0c\u5728\u5f00\u59cb\u5229\u7279\u6614\u66ff\u5c3c(LuciRit)\u6cbb\u7597\u524d\u8003\u8651\u6297\u7ed3\u6838\u6cbb\u7597\uff0c\u5e76\u8003\u8651\u5728\u5229\u7279\u6614\u66ff\u5c3c(LuciRit)\u6cbb\u7597\u671f\u95f4\u7b5b\u67e5 TB \u9ad8\u98ce\u9669\u60a3\u8005\u3002<\/p>\n

 <\/p>\n

\u75c5\u6bd2\u518d\u6d3b\u5316<\/p>\n

\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u62a5\u544a\u4e86\u75c5\u6bd2\u518d\u6fc0\u6d3b\uff0c\u5305\u62ec\u75b1\u75b9\u75c5\u6bd2\u518d\u6fc0\u6d3b\u75c5\u4f8b\uff08\u4f8b\u5982\uff0c\u5e26\u72b6\u75b1\u75b9\uff09[\u53c2\u89c1\u4e0d\u826f\u53cd\u5e94]\u3002\u5982\u679c\u60a3\u8005\u51fa\u73b0\u5e26\u72b6\u75b1\u75b9\uff0c\u8003\u8651\u4e2d\u65ad\u6cbb\u7597\u76f4\u81f3\u4e8b\u4ef6\u6d88\u9000\u3002<\/p>\n

\u5728\u5f00\u59cb\u5229\u7279\u6614\u66ff\u5c3c(LuciRit)\u6cbb\u7597\u524d\uff0c\u5e94\u6309\u7167\u4e34\u5e8a\u6307\u5357\u8fdb\u884c\u75c5\u6bd2\u6027\u809d\u708e\u7b5b\u67e5\u3002\u6709 HIV \u611f\u67d3\u6216\u4e59\u578b\u809d\u708e\u6216\u4e19\u578b\u809d\u708e\u611f\u67d3\u8bc1\u636e\u7684\u60a3\u8005\u4ece\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u6392\u9664\u3002<\/p>\n

 <\/p>\n

\u4e8c\u3001\u6b7b\u4ea1\u7387<\/p>\n

\u5728\u4e00\u9879\u5927\u578b\u3001\u968f\u673a\u3001\u4e0a\u5e02\u540e\u5b89\u5168\u6027\u7814\u7a76\u4e2d\uff0c\u4f7f\u7528\u53e6\u4e00\u79cd JAK \u6291\u5236\u5242\u6cbb\u759750\u5c81\u53ca\u4ee5\u4e0a\u6709\u81f3\u5c11\u4e00\u79cd\u5fc3\u8840\u7ba1\u98ce\u9669\u56e0\u7d20\u7684 RA \u60a3\u8005\uff0c\u53d1\u73b0\u4e0e TNF \u963b\u6ede\u5242\u76f8\u6bd4\uff0c\u4f7f\u7528 JAK \u6291\u5236\u5242\u6cbb\u7597\u7684\u60a3\u8005\u7684\u5168\u56e0\u6b7b\u4ea1\u7387\u66f4\u9ad8\uff0c\u5305\u62ec\u5fc3\u8840\u7ba1\u731d\u6b7b\u3002<\/p>\n

\u5728\u5f00\u59cb\u6216\u7ee7\u7eed\u5229\u7279\u6614\u66ff\u5c3c(LuciRit)\u6cbb\u7597\u524d\uff0c\u8003\u8651\u4e2a\u4f53\u60a3\u8005\u7684\u83b7\u76ca\u548c\u98ce\u9669\u3002<\/p>\n

 <\/p>\n

\u4e09\u3001\u6076\u6027\u80bf\u7624\u548c\u6dcb\u5df4\u589e\u751f\u6027\u75be\u75c5<\/p>\n

\u5728\u5229\u7279\u6614\u66ff\u5c3c(LuciRit)\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u89c2\u5bdf\u5230\u6076\u6027\u80bf\u7624\uff0c\u5305\u62ec\u975e\u9ed1\u8272\u7d20\u7624\u76ae\u80a4\u764c (NMSC)[\u89c1\u4e0d\u826f\u53cd\u5e94]\u3002<\/p>\n

\u5bf9\u4e8e\u76ae\u80a4\u764c\u98ce\u9669\u589e\u52a0\u7684\u60a3\u8005\uff0c\u5efa\u8bae\u5b9a\u671f\u8fdb\u884c\u76ae\u80a4\u68c0\u67e5\u3002<\/p>\n

 <\/p>\n

\u56db\u3001\u4e3b\u8981\u4e0d\u826f\u5fc3\u8840\u7ba1\u4e8b\u4ef6 (MACE)<\/p>\n

\u5728\u53e6\u4e00\u79cd JAK \u6291\u5236\u5242\u6cbb\u759750\u5c81\u53ca\u4ee5\u4e0a\u6709\u81f3\u5c11\u4e00\u79cd\u5fc3\u8840\u7ba1\u98ce\u9669\u56e0\u7d20\u7684 RA \u60a3\u8005\u7684\u5927\u578b\u3001\u968f\u673a\u3001\u4e0a\u5e02\u540e\u5b89\u5168\u6027\u7814\u7a76\u4e2d\uff0c\u4e0e\u63a5\u53d7 TNF \u963b\u6ede\u5242\u6cbb\u7597\u7684\u60a3\u8005\u76f8\u6bd4\uff0c\u4f7f\u7528 JAK \u6291\u5236\u5242\u65f6\u89c2\u5bdf\u5230\u4e3b\u8981\u4e0d\u826f\u5fc3\u8840\u7ba1\u4e8b\u4ef6 (MACE)\uff08\u5b9a\u4e49\u4e3a\u5fc3\u8840\u7ba1\u6b7b\u4ea1\u3001\u975e\u81f4\u6b7b\u6027\u5fc3\u808c\u6897\u6b7b (MI) \u548c\u975e\u81f4\u6b7b\u6027\u5352\u4e2d\uff09\u7684\u53d1\u751f\u7387\u66f4\u9ad8\u3002\u5f53\u524d\u6216\u65e2\u5f80\u5438\u70df\u8005\u7684\u98ce\u9669\u589e\u52a0\u3002<\/p>\n

\u5728\u5f00\u59cb\u6216\u7ee7\u7eed\u5229\u7279\u6614\u66ff\u5c3c(LuciRit)\u6cbb\u7597\u524d\uff0c\u8003\u8651\u4e2a\u4f53\u60a3\u8005\u7684\u83b7\u76ca\u548c\u98ce\u9669\uff0c\u5c24\u5176\u662f\u5728\u5f53\u524d\u6216\u65e2\u5f80\u5438\u70df\u8005\u4ee5\u53ca\u5177\u6709\u5176\u4ed6\u5fc3\u8840\u7ba1\u98ce\u9669\u56e0\u7d20\u7684\u60a3\u8005\u4e2d\u3002\u5e94\u544a\u77e5\u60a3\u8005\u4e25\u91cd\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u7684\u75c7\u72b6\u548c\u53d1\u751f\u65f6\u91c7\u53d6\u7684\u6b65\u9aa4\u3002\u53d1\u751f\u5fc3\u808c\u6897\u6b7b\u6216\u5352\u4e2d\u7684\u60a3\u8005\u5e94\u505c\u7528\u5229\u7279\u6614\u66ff\u5c3c(LuciRit)\u3002<\/p>\n

 <\/p>\n

\u4e94\u3001\u8840\u6813\u6813\u585e<\/p>\n

\u5728\u4e00\u9879\u5927\u578b\u3001\u968f\u673a\u3001\u4e0a\u5e02\u540e\u5b89\u5168\u6027\u7814\u7a76\u4e2d\uff0c\u4f7f\u7528\u53e6\u4e00\u79cd JAK \u6291\u5236\u5242\u6cbb\u759750\u5c81\u53ca\u4ee5\u4e0a\u6709\u81f3\u5c11\u4e00\u79cd\u5fc3\u8840\u7ba1\u98ce\u9669\u56e0\u7d20\u7684 RA \u60a3\u8005\uff0c\u89c2\u5bdf\u5230\u603b\u4f53\u8840\u6813\u5f62\u6210\u3001DVT\u548c PE \u7684\u53d1\u751f\u7387\u9ad8\u4e8e\u63a5\u53d7 TNF \u963b\u6ede\u5242\u6cbb\u7597\u7684\u60a3\u8005\u3002<\/p>\n

\u8840\u6813\u5f62\u6210\u98ce\u9669\u53ef\u80fd\u589e\u52a0\u7684\u60a3\u8005\u5e94\u907f\u514d\u4f7f\u7528\u5229\u7279\u6614\u66ff\u5c3c(LuciRit)\u3002\u5982\u679c\u53d1\u751f\u8840\u6813\u5f62\u6210\u6216\u6813\u585e\u75c7\u72b6\uff0c\u60a3\u8005\u5e94\u4e2d\u65ad\u5229\u7279\u6614\u66ff\u5c3c(LuciRit)\u6cbb\u7597\uff0c\u5e76\u53ca\u65f6\u63a5\u53d7\u8bc4\u4ef7\u548c\u9002\u5f53\u6cbb\u7597\u3002<\/p>\n

 <\/p>\n

\u516d\u3001\u8fc7\u654f<\/p>\n

\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u63a5\u53d7\u5229\u7279\u6614\u66ff\u5c3c(LuciRit)\u7684\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u4e25\u91cd\u53cd\u5e94\uff0c\u5305\u62ec\u8fc7\u654f\u53cd\u5e94\u3001\u8368\u9ebb\u75b9\u548c\u76ae\u75b9\u3002\u5982\u679c\u53d1\u751f\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u8d85\u654f\u53cd\u5e94\uff0c\u505c\u7528\u5229\u7279\u6614\u66ff\u5c3c(LuciRit)\u5e76\u8fdb\u884c\u9002\u5f53\u7684\u6cbb\u7597\u3002<\/p>\n

 <\/p>\n

\u4e03\u3001\u5b9e\u9a8c\u5ba4\u68c0\u67e5\u5f02\u5e38<\/p>\n

\u5229\u7279\u6614\u66ff\u5c3c(LuciRit)\u6cbb\u7597\u4e0e\u6dcb\u5df4\u7ec6\u80de\u548c\u8840\u5c0f\u677f\u51cf\u5c11\u76f8\u5173\u3002\u5728\u5f00\u59cb\u5229\u7279\u6614\u66ff\u5c3c(LuciRit)\u6cbb\u7597\u524d\uff0c\u8fdb\u884c ALC \u548c\u8840\u5c0f\u677f\u8ba1\u6570 [\u89c1\u7528\u6cd5\u7528\u91cf]\u3002\u5f00\u59cb\u5229\u7279\u6614\u66ff\u5c3c(LuciRit)\u6cbb\u7597\u540e\uff0c\u6839\u636e ALC \u548c\u8840\u5c0f\u677f\u8ba1\u6570\u5f02\u5e38\uff0c\u5efa\u8bae\u4e2d\u65ad\u6216\u505c\u6b62\u6cbb\u7597[\u89c1\u7528\u6cd5\u7528\u91cf]\u3002<\/p>\n

 <\/p>\n

\u516b\u3001\u75ab\u82d7\u63a5\u79cd<\/p>\n

\u5c1a\u65e0\u63a5\u53d7\u5229\u7279\u6614\u66ff\u5c3c(LuciRit)\u7684\u60a3\u8005\u5bf9\u75ab\u82d7\u63a5\u79cd\u5e94\u7b54\u7684\u6570\u636e\u3002\u5e94\u907f\u514d\u5728\u6cbb\u7597\u671f\u95f4\u6216\u5f00\u59cb\u6cbb\u7597\u524d\u4e0d\u4e45\u4f7f\u7528\u51cf\u6bd2\u6d3b\u75ab\u82d7\u3002\u5728\u5f00\u59cb \u5229\u7279\u6614\u66ff\u5c3c(LuciRit)\u6cbb\u7597\u524d\uff0c\u5efa\u8bae\u6839\u636e\u73b0\u884c\u514d\u75ab\u63a5\u79cd\u6307\u5357\uff0c\u4f7f\u60a3\u8005\u4e86\u89e3\u6240\u6709\u514d\u75ab\u63a5\u79cd\u7684\u6700\u65b0\u60c5\u51b5\uff0c\u5305\u62ec\u9884\u9632\u6027\u5e26\u72b6\u75b1\u75b9\u75ab\u82d7\u63a5\u79cd\u3002<\/p>\n

 <\/p>\n

\u3010\u7279\u6b8a\u4eba\u7fa4\u7528\u836f\u3011<\/strong><\/p>\n

1\u3001\u598a\u5a20<\/p>\n

\u5982\u679c\u60a3\u8005\u5728\u63a5\u53d7\u5229\u7279\u6614\u66ff\u5c3c(LuciRit)\u671f\u95f4\u6000\u5b55\uff0c\u5e94\u5c3d\u5feb\u54a8\u8be2\u533b\u751f\u3002<\/p>\n

\u5728\u598a\u5a20\u5973\u6027\u4e2d\u4f7f\u7528\u00a0LuciRit\u00a0\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7684\u73b0\u6709\u6570\u636e\u4e0d\u8db3\u4ee5\u786e\u5b9a\u3002\u91cd\u5927\u51fa\u751f\u7f3a\u9677\u3001\u6d41\u4ea7\u6216\u5176\u4ed6\u4e0d\u826f\u6bcd\u4f53\u6216\u80ce\u513f\u7ed3\u5c40\u7684\u836f\u7269\u76f8\u5173\u98ce\u9669\u3002\u5728\u52a8\u7269\u751f\u6b96\u7814\u7a76\u4e2d\uff0c\u6839\u636e\u66f2\u7ebf\u4e0b\u9762\u79ef (AUC) \u6bd4\u8f83\uff0c\u5728\u66b4\u9732\u91cf\u5206\u522b\u4e3a\u6700\u5927\u63a8\u8350\u4eba\u7528\u5242\u91cf (MRHD) \u768449\u500d\u548c55\u500d\u65f6\uff0c\u5728\u5668\u5b98\u5f62\u6210\u671f\u5bf9\u598a\u5a20\u5927\u9f20\u548c\u5bb6\u5154\u7ecf\u53e3\u7ed9\u4e88\u5229\u59a5\u6614\u5355\u6297\u5bfc\u81f4\u80ce\u4ed4\u6bd2\u6027\u548c\u80ce\u4ed4\u7578\u5f62\u3002<\/p>\n

 <\/p>\n

2\u3001\u54fa\u4e73\u671f<\/p>\n

\u7531\u4e8e\u6210\u4eba\u4e2d\u7684\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\uff0c\u5305\u62ec\u4e25\u91cd\u611f\u67d3\u548c\u6076\u6027\u80bf\u7624\u7684\u98ce\u9669\uff0c\u5efa\u8bae\u5973\u6027\u5728\u5229\u7279\u6614\u66ff\u5c3c(LuciRit)\u6cbb\u7597\u671f\u95f4\u548c\u672b\u6b21\u7ed9\u836f\u540e\u7ea614\u5c0f\u65f6\u5185\uff08\u7ea66\u4e2a\u6d88\u9664\u534a\u8870\u671f\uff09\u4e0d\u8981\u54fa\u4e73\u3002<\/p>\n

 <\/p>\n

3\u3001\u513f\u7ae5\u7528\u836f<\/p>\n

\u5df2\u572812\u5c81\u53ca\u4ee5\u4e0a\u513f\u7ae5\u60a3\u8005\u4e2d\u786e\u5b9a\u4e86\u5229\u7279\u6614\u66ff\u5c3c(LuciRit)\u6cbb\u7597\u6591\u79c3\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u5c1a\u672a\u786e\u5b9a\u5229\u7279\u6614\u66ff\u5c3c(LuciRit)\u572812\u5c81\u4ee5\u4e0b\u513f\u79d1\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u7597\u6548\u3002<\/p>\n

 <\/p>\n

4\u3001\u8001\u5e74\u60a3\u8005\u7528\u836f<\/p>\n

\u226565\u5c81\u7684\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002\u5229\u7279\u6614\u66ff\u5c3c(LuciRit)\u7684\u4e34\u5e8a\u8bd5\u9a8c\u672a\u7eb3\u5165\u8db3\u591f\u6570\u91cf\u768465\u5c81\u53ca\u4ee5\u4e0a\u60a3\u8005\uff0c\u56e0\u6b64\u65e0\u6cd5\u786e\u5b9a\u5176\u53cd\u5e94\u662f\u5426\u4e0e\u5e74\u8f7b\u6210\u4eba\u60a3\u8005\u4e0d\u540c\u3002\u7531\u4e8e\u4e00\u822c\u8001\u5e74\u4eba\u7fa4\u7684\u611f\u67d3\u53d1\u751f\u7387\u8f83\u9ad8\uff0c\u56e0\u6b64\u6cbb\u7597\u8001\u5e74\u4eba\u65f6\u5e94\u8c28\u614e\u3002<\/p>\n

 <\/p>\n

5\u3001\u809d\u635f\u5bb3<\/p>\n

\u8f7b\u5ea6 (Child Pugh A) \u6216\u4e2d\u5ea6 (Child Pugh B) \u809d\u635f\u5bb3\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002<\/p>\n

\u4e0d\u5efa\u8bae\u91cd\u5ea6\uff08Child Pugh C\u7ea7\uff09\u809d\u635f\u5bb3\u60a3\u8005\u4f7f\u7528\u5229\u7279\u6614\u66ff\u5c3c(LuciRit)[\u89c1\u7528\u6cd5\u7528\u91cf]\u3002<\/p>\n

\u3010\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u3011<\/strong><\/p>\n

\u4e00\u3001\u5229\u7279\u6614\u66ff\u5c3c\u5bf9\u5176\u4ed6\u836f\u7269\u7684\u5f71\u54cd<\/p>\n

1\u3001\u6d53\u5ea6\u5c0f\u5e45\u53d8\u5316\u53ef\u80fd\u5bfc\u81f4\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\u7684 CYP3A \u5e95\u7269<\/p>\n

\u5229\u7279\u6614\u66ff\u5c3c\u662f\u4e00\u79cd CYP3A \u6291\u5236\u5242\u3002\u5408\u5e76\u4f7f\u7528\u5229\u7279\u6614\u66ff\u5c3c\u53ef\u589e\u52a0 CYP3A \u5e95\u7269\u7684 AUC \u548c Cmax\uff0c\u8fd9\u53ef\u80fd\u4f1a\u589e\u52a0\u8fd9\u4e9b\u5e95\u7269\u53d1\u751f\u4e0d\u826f\u53cd\u5e94\u7684\u98ce\u9669\u3002<\/p>\n

\u5904\u7406\u63aa\u65bd\uff1a\u6839\u636e\u83b7\u6279\u7684 CYP3A \u5e95\u7269\u4ea7\u54c1\u8bf4\u660e\u4e66\u8003\u8651\u8fdb\u884c\u989d\u5916\u76d1\u6d4b\u548c\u5242\u91cf\u8c03\u6574\uff0c\u5176\u4e2d\u4f7f\u7528\u65f6\u6d53\u5ea6\u5fae\u5c0f\u53d8\u5316\u53ef\u80fd\u5bfc\u81f4\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\u3002<\/p>\n

2\u3001\u6d53\u5ea6\u5c0f\u5e45\u53d8\u5316\u53ef\u80fd\u5bfc\u81f4\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\u7684 CYP1A2 \u5e95\u7269<\/p>\n

\u5229\u7279\u6614\u66ff\u5c3c\u662f\u4e00\u79cd CYP1A2 \u6291\u5236\u5242\u3002\u5408\u5e76\u4f7f\u7528\u5229\u7279\u6614\u66ff\u5c3c\u53ef\u589e\u52a0 CYP1A2 \u5e95\u7269\u7684 AUC \u548c Cmax\uff0c\u8fd9\u53ef\u80fd\u4f1a\u589e\u52a0\u8fd9\u4e9b\u5e95\u7269\u53d1\u751f\u4e0d\u826f\u53cd\u5e94\u7684\u98ce\u9669\u3002<\/p>\n

\u5904\u7406\u63aa\u65bd\uff1a\u5982\u679c\u98ce\u9669\u8f83\u5c0f\uff0c\u8003\u8651\u6839\u636e\u83b7\u6279\u7684 CYP1A2 \u5e95\u7269\u4ea7\u54c1\u8bf4\u660e\u4e66\u8fdb\u884c\u989d\u5916\u76d1\u6d4b\u548c\u5242\u91cf\u8c03\u6574\u5f53\u4e0e\u5229\u7279\u6614\u66ff\u5c3c\u4f34\u968f\u4f7f\u7528\u65f6\uff0c\u6d53\u5ea6\u53d8\u5316\u53ef\u80fd\u5bfc\u81f4\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\u3002<\/p>\n

\u4e8c\u3001\u5176\u4ed6\u836f\u7269\u5bf9\u5229\u59a5\u6614\u5355\u6297\u7684\u5f71\u54cd<\/p>\n

1\u3001CYP3A \u8bf1\u5bfc\u5242<\/p>\n

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