DABRAMAKS 75 Generic name: Dabrafenib capsules/Dabrafenib

The following is the general instructions for use of Dabrafenib. Please follow your doctor's advice for specific use.

Drug name <br>Generic name: Dabrafenib

Indications <br>Dabrafenib is a kinase inhibitor used primarily to treat the following diseases:

1. Melanoma : Indicated for patients with unresectable or metastatic melanoma that is BRAF V600E or V600K mutation-positive.
2. Non-small cell lung cancer (NSCLC) : Suitable for patients with metastatic non-small cell lung cancer who are BRAF V600E mutation-positive.
3. Thyroid cancer : used in combination with trametinib, it is indicated for locally advanced or metastatic thyroid cancer that is BRAF V600E mutation-positive.

Mechanism of action <br>Dabrafenib is a BRAF kinase inhibitor that specifically inhibits the protein activity of the V600 mutation in the BRAF gene, thereby blocking the proliferation of tumor cells.

Dosage

• Adult Dosage : The recommended dose is 150 mg twice daily on an empty stomach (at least 1 hour before or 2 hours after a meal).
• Combination therapy : If used in combination with trametinib, the dose should be adjusted according to the specific treatment plan.

Precautions

1. Genetic testing : Before treatment, it is necessary to confirm whether the patient carries the BRAF V600 mutation.
2. Side Effect Monitoring :
   • Common side effects include fever, fatigue, nausea, vomiting, joint pain, rash, etc.
   • Serious side effects include new malignant tumors, abnormal liver function, high blood sugar, eye problems, etc.
3. Special groups : Pregnant women, lactating women and children should use it with caution and consult a doctor if necessary.
4. Drug interactions : Avoid co-administration with CYP3A4 inducers or inhibitors.

Contraindications <br>This drug is contraindicated in patients who are allergic to dabrafenib or its excipients.

Storage conditions

• Store below 25°C away from heat, moisture and light.
• Keep out of reach of children.

Note <br>This medicine should be used under the guidance of a doctor with experience in tumor treatment. For more information, please refer to the full instructions or consult your healthcare provider.

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