TRAMAKS 2 Trametinib 2mg 30s

The following is the general instructions for Trametinib, which is for reference only. Please follow the doctor's advice or the instructions in the drug package for specific use.

Drug Name

Generic name: Trametinib

Indications

Trametinib is a MEK kinase inhibitor used for the following indications:

1. Melanoma :
   • It is indicated as a single agent or in combination with dabrafenib for patients with unresectable or metastatic BRAF V600E or V600K mutation-positive melanoma.
2. Non-small cell lung cancer (NSCLC) :
   • In combination with dabrafenib, it is indicated for patients with metastatic non-small cell lung cancer who are BRAF V600E mutation-positive.
3. Thyroid cancer :
   • In combination with dabrafenib, it is indicated for locally advanced or metastatic thyroid cancer that is BRAF V600E mutation-positive.

Mechanism of action

Trametinib inhibits the activity of MEK1 and MEK2 protein kinases, blocking the RAS/RAF/MEK/ERK signaling pathway, thereby inhibiting the proliferation and growth of tumor cells.

Dosage

• Recommended dose :
  • Single drug: 2 mg once a day.
  • Combination therapy: When used in combination with dabrafenib, the dose needs to be adjusted according to the combined treatment regimen.
• Directions :
  • Take on an empty stomach (at least 1 hour before or 2 hours after a meal).

Precautions

1. Genetic testing :
   • Before treatment, it is necessary to confirm whether the patient carries the BRAF V600 mutation.
2. Side Effect Monitoring :
   • Common side effects : fatigue, rash, diarrhea, nausea, vomiting, peripheral edema, stomatitis, etc.
   • Serious side effects : heart failure, retinal detachment, thrombotic events, skin toxicity, interstitial lung disease, etc.
3. Special Populations :
   • Pregnant and breastfeeding women should avoid use.
   • The safety and effectiveness of medication for children and elderly patients need to be adjusted based on the doctor's advice.
4. Drug Interactions :
   • Avoid co-administration with CYP3A4 inducers or inhibitors.

Contraindications

• Patients who are allergic to trametinib or its excipients are contraindicated.

Storage conditions

• Store at 2°C to 8°C (refrigerated).
• Avoid freezing and direct sunlight. Keep out of reach of children.

Important Tips

• Trametinib should be used under the guidance of a physician with experience in tumor treatment.
• During treatment, heart function, liver function, and eye health should be checked regularly.
• Please read the instructions on the medicine package carefully or ask your healthcare provider for more information.

If you need more detailed information or specific treatment plans for a certain indication, you can consult further!