Capmatinib is used to treat adult patients with metastatic non-small cell lung cancer (NSCLC)

Capmatinib tablets (LuciCapma) simple instructions

Please use under the guidance of a physician

Product Name: LuciCapma

Manufacturer: Lucius Pharmaceuticals (Laos) Co., Ltd.

Chinese name: Capmatinib tablets

English name: Capmatinib tablets

Drug approval number: 07 L 0996/23

 

【Indications】

LuciCapma is indicated for the treatment of adult patients with metastatic non-small cell lung cancer (NSCLC) whose tumors have a mesenchymal-epithelial transition (MET) exon 14 skipping mutation as determined by an FDA-approved test.

 

【Usage and Dosage】

•Select patients for LuciCapma treatment based on the presence or absence of a MET exon 14 skipping mutation.

•Recommended dose: 400 mg orally twice daily, with or without food.

【Specification】

200 mg/tablet, 60 tablets/box.

 

【 Contraindications 】

none

 

【 Warnings and Precautions 】

•Interstitial Lung Disease (ILD)/Pneumonitis: Monitor for new or worsening pulmonary symptoms indicative of ILD/pneumonitis. Permanently discontinue LuciCapma in patients with ILD/pneumonitis.

• Hepatotoxicity: Monitor liver function tests. Based on severity, withhold, reduce dose, or permanently discontinue LuciCapma.

• Pancreatic toxicity: Monitor amylase and lipase levels. Based on severity, withhold, reduce dose, or permanently discontinue LuciCapma.

•Hypersensitivity reactions: Withhold or permanently discontinue LuciCapma depending on severity.

• Photosensitivity risk: May cause photosensitivity reactions. Advise patients to limit direct exposure to UV rays.

• Embryo-fetal toxicity: May cause harm to the fetus. Inform patients of the potential risk to the fetus and use effective contraception.

 

【Adverse Reactions】

The most common adverse reactions (≥20%) were edema, nausea, musculoskeletal pain, fatigue, vomiting, dyspnea, cough, and decreased appetite.

 

【Drug Interactions】

Avoid concomitant use with strong and moderate CYP3A inducers.

 

【Use by specific groups】

Lactation: Breastfeeding is not recommended.

 

【Storage】

Store in original packaging with desiccant.

Storage temperature is 20℃ to 25℃ (68℉ to 77℉), short-distance transportation is allowed between 15℃ to 30℃ (59℉ to 86℉). Protect from moisture.

Throw away unused LuciCapma 6 weeks after you first open the bottle.