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大熊制药

Selumetinib, SEMEDX, Selumetinib, 10mg Manufacturer: Laos Daxiong Pharmaceutical Introduction: 10mg*60 capsules

Selumetinib, SEMEDX, Selumetinib, 10mg Manufacturer: Laos Daxiong Pharmaceutical Introduction: 10mg*60 capsules

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Selumetinib, SEMEDX, Selumetinib, 10mg/25mg

Manufacturer: Laos Daxiong Pharmaceutical

Description: 10mg*60 capsules

Indications

Selumetinib is indicated for the treatment of inoperable plexiform neurofibromas (PN) in children aged 2 years and older with neurofibromatosis type 1 (NF1).

Recommended dose

  • The recommended dose of selumetinib is 25 mg/m2 orally twice a day (approximately every 12 hours) until disease progression or unacceptable toxicity.
  • Take selumetinib on an empty stomach.
  • Do not eat food 2 hours before or 1 hour after each dose.

The following is the recommended dose of selumetinib based on body surface area (BSA).

Recommended dose based on body surface area


Body surface area Recommended dose
0.55 – 0.69 m 2 20 mg in the morning, 10 mg in the evening
0.70 – 0.89 m 2 20 mg twice daily
0.90 – 1.09 m 2 25 mg twice daily
1.10 – 1.29 m 2 30 mg twice daily
1.30 – 1.49 m 2 35 mg twice daily
1.50 – 1.69 m 2 40 mg twice daily
1.70 – 1.89 m 2 45 mg twice daily
≥1.90 m2 50 mg twice daily
* The recommended dose for patients with BSA less than 0.55 m2 has not been established.


  • Swallow selumetinib capsule whole with water.
  • Do not chew, dissolve or open the capsule.
  • Do not administer to patients who are unable to swallow the capsule whole.
  • Do not take a missed dose of selumetinib until your next scheduled dose, unless it is more than 6 hours before the missed dose.
  • If you vomit after taking selumetinib, do not take another dose and continue with your next scheduled dose.
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