1 1

东盟制药

Ventok VENETOCLAX 10mg 14 tablets Approval No. 12 L 0756/17 Expiry Date 25-8-2027

Ventok VENETOCLAX 10mg 14 tablets Approval No. 12 L 0756/17 Expiry Date 25-8-2027

¥200.00 CNY
¥500.00 CNY ¥200.00 CNY
Sale Sold out
Shipping calculated at checkout.

Ventok, brand name: Venetoclax, generic name: Venetoclax, also known as Ventoclax, Venetola. A BCL-2 inhibitor indicated for the treatment of patients with chronic lymphocytic leukemia (CLL) with 17p deletion as detected by an FDA-approved test. Specifications: 10mg, 50mg, 100mg

Drug Introduction

Venetoclax is a BCL-2 inhibitor that works by targeting and inhibiting the BCL-2 protein and is mainly used for the following indications:
• Chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL).
• Acute myeloid leukemia (AML).

Usage and Dosage

Chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL)
• Initial dose escalation:
• Week 1: 20 mg once daily.
• Week 2: 50 mg once daily.
• Week 3: 100 mg once daily.
• Week 4: 200 mg once daily.
• Week 5 and beyond: 400 mg once daily (maintenance dose).
• Directions:
• Take with food, swallow the tablet whole without chewing, breaking or crushing.

Acute Myeloid Leukemia (AML)
• Used in combination with azacitidine or decitabine: The usual initial dose is 400 mg once daily. The specific dose and course of treatment should be based on the doctor's advice.

Precautions

Common adverse reactions
• Hematologic: neutropenia, anemia, thrombocytopenia.
• Digestive system: nausea, diarrhea, vomiting.
• Others: fatigue, musculoskeletal pain, upper respiratory tract infection.

Serious adverse reactions
• Tumor lysis syndrome (TLS): It may be caused by the rapid rupture of tumor cells in the initial stage of taking the drug. Preventive measures should be taken under the guidance of a doctor (such as adequate hydration, taking allopurinol or rituximab).
• Infection: The risk of infection may increase while taking this medication, so pay attention to signs of infection (such as fever, cough).

Contraindications
• It is contraindicated in patients who are allergic to Venetoclax or its ingredients.
• Use with caution in patients with severe hepatic impairment.

Use in Special Populations
• Pregnant and lactating women: May be toxic to the fetus. Pregnant women are prohibited from using this drug. Lactating women should stop breastfeeding or discontinue the drug.
• Elderly patients: No special dose adjustment is required, but attention should be paid to the risk of infection.

Drug interactions
1. Avoid co-use with strong CYP3A4 inhibitors (such as clarithromycin, ketoconazole) or inducers (such as rifampicin, phenobarbital).
2. Use with caution when used in combination with anticoagulants (such as warfarin), as this may increase the risk of bleeding.

Check before taking medicine
• A routine blood test is required to assess baseline status before starting treatment and to monitor regularly during treatment.

Special reminder
• Take the medicine under the supervision of a doctor and avoid adjusting the dose or stopping the medicine on your own.
• When taking the medicine, you must drink enough water to prevent the occurrence of tumor lysis syndrome.
• Always be aware of adverse reactions and seek medical attention immediately if you experience any unusual symptoms.

This medicine must be used strictly according to the doctor's instructions. If you have further questions, please consult your doctor or pharmacist.
View full details