Conafenib, BRATODX, Encorafenib

1. Name of drug

• Generic Name : Encorafenib
• Product Name :

2. Indications

Encorafenib is commonly used for the following conditions:

• Unresectable or metastatic melanoma : In combination with binimetinib , for the treatment of melanoma harboring BRAF V600E or V600K mutations.
• BRAF V600E mutated advanced colorectal cancer (mCRC): combined with cetuximab , for patients who have previously received chemotherapy.

3. Usage and Dosage

• Melanoma : For melanoma, the recommended dose is encorafenib 450 mg orally once daily, taken with binimetinib 45 mg orally twice daily.
• Colorectal Cancer : For colorectal cancer, the recommended dose is Encorafenib 300 mg orally once daily in combination with cetuximab .

4. Adverse reactions

Common side effects include:

• Skin reactions : such as rash, hand-foot syndrome (dry and red skin on the hands and feet, etc.).
• Fatigue , headache, fever.
• Gastrointestinal symptoms : such as nausea, vomiting, and diarrhea.
• Joint pain or muscle pain.
• Liver impairment : including elevated transaminases.
• Eye problems : such as blurred vision, dry eyes, etc.

Serious adverse reactions may include:

• Severe bleeding and thrombosis .
• Heart problems , such as heart failure.
• Allergic reactions such as anaphylactic shock.

5. Contraindications

• Patients with hypersensitivity to Encorafenib or any of its ingredients.
• Pregnant and breastfeeding women usually need to avoid this medication because the medication may harm the fetus or baby.

6. Notes

• Liver Function Monitoring : Periodic monitoring of liver function may be necessary during use of Encorafenib.
• Skin reactions : This drug may cause a rash or other skin problems. Pay attention to skin changes when using it.
• Bleeding Risk : Encorafenib may increase the risk of bleeding and should be used with caution.
• Drug interactions : Encorafenib may interact with certain drugs, especially those that affect liver metabolizing enzymes (such as CYP3A4 inhibitors or inducers). Before starting treatment, you should tell your doctor about all the drugs you are taking.

7. Drug Interactions

Encorafenib may interact with other drugs, especially those that affect liver metabolism (such as inhibitors or inducers of CYP3A4). Therefore, special attention should be paid to drug interactions when using this drug.

8. Get the complete manual

If you need to get the full Encorafenib package insert, you can:

1. Consult your doctor or pharmacist : they will provide you with the most detailed information about the medicine.
2. Medicine packaging : Medicine packaging usually comes with detailed instructions for the medicine.
3. Official website : You can visit the official website of the manufacturer of Encorafenib (such as Boston Pharmaceuticals) to view detailed instructions.

If you have any specific questions about the use of Encorafenib , or need further explanation, please feel free to ask!