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Trestagliptin TRELAGLIPTIN 100MG 4 tablets Approval No. 09 L 0703/16 Expiry Date 27-6-2026

Trestagliptin TRELAGLIPTIN 100MG 4 tablets Approval No. 09 L 0703/16 Expiry Date 27-6-2026

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The following is the generic drug package insert for **Trelagliptin (trade name: Zafatek)**.

Drug instructions

Drug Name

  • Generic Name: Telagliflozin
  • Product Name: Trestin
  • English name: Trelagliptin

Pharmacological action and mechanism

Tralagliptin is a long-acting dipeptidyl peptidase-4 (DPP-4) inhibitor that inhibits the activity of the DPP-4 enzyme, delays the degradation of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulin-releasing polypeptide (GIP), enhances insulin secretion, and inhibits glucagon secretion, thereby improving blood sugar control.

Indications

  1. For the treatment of type 2 diabetes mellitus (T2DM) in adults, as an adjunct to diet and exercise to improve blood sugar levels.
  2. It can be used alone or in combination with other glucose-lowering drugs (such as metformin and sulfonylureas).

Dosage

  1. Recommended dose
    • 100 mg orally once a week.
  2. Directions
    • Can be taken with or without food.
    • It is recommended to take the medication at a fixed time, ensuring that the interval is consistent every week.
  3. Special Populations
    • Patients with impaired renal function : Patients with moderate or severe renal impairment require dose adjustment or use with caution.
    • Elderly patients : No special adjustments are required, but renal function needs to be monitored.

Contraindications

  • Patients with hypersensitivity to tralagliptin or any of its ingredients.
  • People with type 1 diabetes or diabetic ketoacidosis.

Precautions

  1. Risk of hypoglycemia
    • The risk of hypoglycemia may be increased when used in combination with insulin or sulfonylureas, and the dose should be adjusted.
  2. pancreatitis
    • Patients with a history of acute pancreatitis should use this drug with caution. If persistent abdominal pain occurs, the drug should be discontinued and the pancreatic condition should be evaluated.
  3. Renal function monitoring
    • Renal function should be assessed prior to and periodically during treatment.
  4. Other considerations
    • If a severe allergic reaction (such as rash, difficulty breathing) occurs during medication, stop the medication immediately and seek medical attention.

Adverse Reactions

  1. Common adverse reactions
    • Upper respiratory tract infection
    • Headache
    • diarrhea
    • nausea
  2. Rare but serious adverse reactions
    • Acute pancreatitis
    • Allergic skin reactions (such as hives, rash)

Drug interactions

  1. Diabetes-lowering drugs
    • Concomitant use with sulfonylureas or insulin may increase the risk of hypoglycemia.
  2. CYP450 enzymes
    • Telagliptin is mainly excreted through the kidneys and is not metabolized by CYP450, so the risk of interaction with CYP450-related drugs is low.

Overdose

  • Symptoms : May include severe hypoglycemia or gastrointestinal upset.
  • Treatment : Symptomatic treatment, no specific antidote.

Storage conditions

  • Store at room temperature (15-30°C), away from direct sunlight and humidity.
  • Keep out of reach of children.

Packing Specifications

  • 100 mg/tablet, 4 tablets per pack.

Manufacturer

Laos ASEAN Pharmaceuticals.

Approval No.

09L0703/16.

Note : This instruction manual is for reference only. Please read the actual instructions of the medicine carefully and use it according to the doctor's advice.

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