Deucravacitinib, DUVACIDX, Deucravacitinib 6mg

Manufacturer: Laos Daxiong Pharmaceutical

Introduction: Deucravacitinib is a new drug used to treat autoimmune diseases. Autoimmune diseases are a class of diseases caused by abnormal immune system attacks on normal tissues and organs of the body, such as rheumatoid arthritis, psoriasis, ankylosing spondylitis and Sjögren's syndrome. Deucravacitinib belongs to a class of drugs called JAK inhibitors. JAK is a tyrosine kinase that is involved in regulating the signal transduction pathways of immune cells. By inhibiting the activity of JAK, Deucravacitinib can interfere with the inflammatory and immune processes and effectively control the symptoms of the disease.

【 Drug name 】

name:  Deuterated Celexitinib Tablets

Product name: DUVACIDX

 

【 Specification 】

6 mg

 

【Indications】

DUVACIDX is a prescription medicine used to treat adults with moderate to severe plaque psoriasis. These patients may benefit from injections or medications (systemic treatments) or treatments using ultraviolet or UV rays (phototherapy). It is not known if DUVACIDX is safe and effective in children younger than 18 years old.

 

【Recommended dosage】

• Take DUVACIDX exactly as your healthcare provider tells you to.

•Take DUVACIDX 1 time per day.

•Take DUVACIDX with or without food.

•Do not crush, cut, or chew DUVACIDX tablets.

 

【side effect】

DUVACIDX may cause serious side effects, including:

oIncrease in triglycerides.

Triglycerides are a type of fat found in your blood. Too much of this fat in your body can cause problems for your heart.

oIncreased liver enzymes.

Liver enzymes are found in your blood and help tell if your liver is functioning properly.

Usually. If your liver enzymes increase too much, your healthcare provider may need to do additional testing.

If they think DUVACIDX is harming your liver, they may tell you to stop taking DUVACIDX.

o Potential risks of Janus kinase (JAK) inhibition.

DUVACIDX is a tyrosine kinase 2 (TYK2) inhibitor. TYK2 is from the JAK family. It is not known if taking DUVACIDX carries the same risks as taking JAK inhibitors. People 50 years and older with at least 1 condition have an increased risk of death (from all causes). People who are taking JAK inhibitors for rheumatoid arthritis (RA) have higher risk factors for heart disease (cardiovascular) than those who are taking another medicine in the TNF blocker class of medicines. DUVACIDX is not for use in people with RA.

The most common side effects of DUVACIDX include:

o Common cold, sore throat and sinus infection (upper respiratory tract infection) o Cold sores (herpes simplex)

oUlcers on the inner lips, gums, tongue, or roof of the mouth oMouth (canker sores)

o Inflammation of hair follicles (folliculitis) o Acne

All possible side effects of DUVACIDX.

Call your doctor for medical advice about side effects.

If you develop symptoms of a severe allergic reaction, stop taking DUVACIDX and get emergency medical help right away.

Any of the following symptoms of a severe allergic reaction:

o Feeling dizzy o Swelling of your face, eyelids, lips, mouth, tongue or throat

o Difficulty breathing or throat tightness o Chest tightness

o Rash, urticaria

Infections: DUVACIDX is a medicine that affects your immune system. It can lower your immune system's ability to fight off infections, but it can increase your risk of getting an infection.

Infections, such as lung infections, including pneumonia and tuberculosis (TB), and COVID -19 , can occur while taking DUVACIDX .

o Before starting treatment with DUVACIDX, your healthcare provider should check you for infections and tuberculosis.

o If you have tuberculosis, your healthcare provider may tell you before you start treatment with DUVACIDX if you have a history of tuberculosis or have active tuberculosis.

oYour healthcare provider should watch you closely for signs and symptoms of TB during treatment.

oIf you get a serious infection, your healthcare provider may tell you to stop taking DUVACIDX until your infection is under control.

DUVACIDX should not be used in patients with active serious infections, including localized infections.

Before starting DUVACIDX , tell your healthcare provider if you:

o Are being treated for an infection o The infection does not go away or keeps coming back

o Have tuberculosis or have had close contact with someone with tuberculosis o Have or have had hepatitis B or C

Think you have an infection or have symptoms of an infection, such as:

o Fever, sweats or chills o Muscle aches o Weight loss

o Cough o Shortness of breath o Blood in sputum (mucus)

o Warmth, redness, or pain on the skin of the body, or ulcers that appear different from other conditions o Psoriasis

o Diarrhea or stomach pain o Burning sensation when urinating or urinating more often than normal    o Feeling very tired

After you start taking DUVACIDX, call your healthcare provider right away if you have an infection or have any symptoms of an infection.

DUVACIDX may make you more likely to get infections or make any infections you have worse.

o Cancer. Certain types of cancer, including lymphoma, have been reported in people taking DUVACIDX.

o Tell your healthcare provider if you have ever had any type of cancer.

o Muscle problems (rhabdomyolysis). DUVACIDX may cause serious muscle problems. Treatment with DUVACIDX may increase the level of an enzyme called creatine phosphokinase (CPK) in your blood and can be a sign of muscle damage. Elevated CPK is common in people taking DUVACIDX. You may be told to stop taking DUVACIDX if your blood levels of CPK are too high or if you have signs and symptoms of serious muscle problems. Tell your healthcare provider right away if you have any of these signs or symptoms.

Symptoms of severe muscle problems:

o Unexplained muscle pain, tenderness, or weakness o Feeling very tired

o Fever o Dark urine

 

【store】

DUVACIDX should be stored at room temperature between 68°F and 86°F (20°C and 30°C).

Keep DUVACIDX and all medicines out of the reach of children.