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CRIZOMAKS 250 rizotinib250mg 60 tablets

CRIZOMAKS 250 rizotinib250mg 60 tablets

¥1,200.00 CNY
¥1,200.00 CNY
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The following is the generic drug instructions for **Crizotinib (trade name: CRIZOMAKS)**.

Drug instructions

Drug Name

  • Generic name: Crizotinib
  • Product Name: CRIZOMAKS
  • English name: Crizotinib

Pharmacological action and mechanism

Crizotinib is a multi-target tyrosine kinase inhibitor that mainly acts on:

  1. Anaplastic lymphoma kinase (ALK)
  2. ROS1
  3. c-Met (HGF receptor)

By inhibiting these kinases, crizotinib blocks cell proliferation and tumor growth signals associated with these pathways.

Indications

  1. ALK-positive non-small cell lung cancer (NSCLC)
    • For the treatment of patients with advanced or metastatic NSCLC who are positive for ALK gene rearrangement.
  2. ROS1-positive non-small cell lung cancer
    • For the treatment of patients with advanced or metastatic NSCLC with positive ROS1 gene rearrangement.

Dosage

  1. Recommended dose
    • 250 mg, orally, twice a day.
  2. Directions
    • Can be taken with or without food, with water.
  3. Dosage Considerations
    • Depending on adverse reactions (such as abnormal liver function, gastrointestinal discomfort, etc.), the dose can be reduced to 200 mg twice a day, or further reduced to 250 mg once a day.

Contraindications

  • Patients with hypersensitivity to crizotinib or any of its components.

Precautions

  1. Liver function monitoring
    • Crizotinib may cause liver damage. It is recommended to monitor liver function (ALT, AST, bilirubin) regularly before and during treatment.
  2. Interstitial lung disease/pneumonia
    • New or worsening respiratory symptoms (e.g., cough, shortness of breath) should be discontinued and the patient evaluated immediately.
  3. QT interval prolongation
    • It is recommended to monitor ECG and use with caution in patients at high risk of QT prolongation.
  4. Visual impairment
    • Some patients may experience visual symptoms (eg, blurred vision, double vision), which are usually mild and reversible.
  5. Childbirth and breastfeeding
    • Crizotinib may cause embryo-fetal toxicity. Female and male patients of childbearing age should take effective contraceptive measures. Breastfeeding women should avoid using it.

Adverse Reactions

  1. Common adverse reactions
    • nausea
    • Vomit
    • diarrhea
    • Decreased appetite
    • fatigue
    • Peripheral edema
    • Visual impairment
  2. Serious adverse reactions
    • Abnormal liver function
    • Interstitial lung disease/pneumonia
    • QT interval prolongation
    • Arrhythmias

Drug interactions

  1. CYP3A4 inhibitors/inducers
    • Strong CYP3A4 inhibitors (such as ketoconazole) may increase the plasma concentration of crizotinib, and strong inducers (such as rifampin) may reduce its efficacy.
  2. Other QT-prolonging drugs
    • Caution is advised when using this drug in combination with drugs that may prolong the QT interval.

Overdose

  • Symptoms : May include gastrointestinal discomfort, QT interval prolongation, etc.
  • Treatment : There is currently no specific antidote, so the drug should be stopped immediately and symptomatic supportive treatment should be given.

Storage conditions

  • Store at 20-25°C away from moisture and light.
  • Keep out of reach of children.

Packing Specifications

  • 200 mg/capsule, 60 capsules.

Manufacturer

Laos State-Owned Factory No. 2.

Approval No.

See the drug packaging for details.

Note : This instruction manual is for reference only. Please read the actual instructions of the drug carefully and use it according to the doctor's instructions.

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