PHOTAFE 25 Drug name: PHOTAFE 25 Generic name: Tenofovir Alafenamide Tablets

The following is the general instructions for Tenofovir Alafenamide (TAF) for reference only. Please refer to the instructions in the drug package for specific use and follow the doctor's instructions.

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Drug Name

Generic Name: Tenofovir Alafenamide (TAF)
Product Name: PHOTAFE

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Indications

Tenofovir alafenamide is an antiviral medicine used primarily to treat the following conditions:

1. Chronic hepatitis B virus infection :
   • For the treatment of adult patients with chronic hepatitis B, especially those who have received anti-hepatitis B virus treatment.
2. HIV-1 infection :
   • As a component of combination antiretroviral therapy (cART) for the treatment of HIV-1 infection in adults.

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Mechanism of action

Tenofovir alafenamide is a nucleoside (acid) reverse transcriptase inhibitor (NRTI) that blocks the replication of hepatitis B virus and HIV by inhibiting reverse transcriptase activity, thereby effectively reducing viral load and helping to control infection.

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Dosage

• Recommended dose :
  • For the treatment of chronic hepatitis B : 25 mg orally, once daily.
  • Treatment of HIV-1 infection : used in combination with other antiretroviral drugs, 25 mg orally once daily.
• Directions :
  • May be taken with or without food. Tablets should be swallowed whole and should not be crushed, chewed or split.

Dosage adjustments :

• For patients with renal insufficiency, the dose needs to be adjusted according to the renal filtration function.

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Precautions

1. Side Effect Monitoring :

   • Common side effects : headache, nausea, diarrhea, fatigue, insomnia, loss of appetite, etc.
   • Serious side effects : abnormal kidney function, lactic acidosis, decreased bone density, abnormal liver function, etc.

2. Use in special populations :

   • Pregnant and lactating women : Based on the doctor's evaluation, it should be used with caution during pregnancy, but tenofovir alafenamide may be one of the first choice drugs for the treatment of hepatitis B and HIV infection. When used during lactation, careful decisions should be made and the use of drugs with infants should be avoided.
   • Children : Safety and effectiveness for use in children under 18 years of age have not been established.
   • Elderly : For older patients or those with renal impairment, this drug should be used with caution and renal function should be monitored regularly.

3. Other notes :

   • Regular monitoring of renal function, bone density, and liver function is required.
   • For patients taking anti-HIV treatment, drug interactions should be considered when other drugs are used in combination.

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Drug interactions

• Nephrotoxic drugs : When used in combination with other nephrotoxic drugs (such as aminoglycoside antibiotics, antifungal drugs, etc.), attention should be paid to renal function monitoring.
• CYP3A4 inducers : such as rifampicin and St. John's wort, may reduce the efficacy of tenofovir alafenamide and should be avoided in combination.
• Combination with other NRTIs : Combination with other known nucleoside reverse transcriptase inhibitors should be avoided to reduce the risk of drug resistance.

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Contraindications

• Patients who are allergic to tenofovir alafenamide or its excipients are contraindicated.
• Pregnant and lactating women should use it with caution based on a physician's evaluation.

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Storage conditions

• Store in a dry environment at 20°C to 25°C, away from heat, humidity and direct sunlight.
• Keep this medicine out of the reach of children.

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Important Tips

• The use of tenofovir alafenamide should be carried out under the guidance of a physician with experience in treating relevant infections.
• Monitor renal function, bone density, and liver function regularly, particularly with long-term use.
• If serious adverse reactions occur, such as decreased renal function, decreased bone density, or lactic acidosis, seek medical attention immediately and stop taking the drug.

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Note : If you need more detailed information or special case medication plans, please consult your doctor or pharmacist. If you have any other questions, please let me know!